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Simvastatin

A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.

Year introduced: 1998

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Subheadings:

Tree Number(s): D02.455.426.559.847.638.400.900, D04.615.638.400.900

MeSH Unique ID: D019821

Registry Number: AGG2FN16EV

Entry Terms:

  • Zocor
  • MK-733
  • MK 733
  • MK733
  • Synvinolin

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Pharmacologic Action:

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