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The prototypical and most well-studied member of the semaphorin family. Semaphorin-3A is an axon-repulsive guidance cue for migrating neurons in the developing nervous system. It has so far been found only in vertebrates, and binds to NEUROPILIN-1/plexin complex receptors on growth cones. Like other class 3 semaphorins, it is a secreted protein.

Year introduced: 2003

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Tree Number(s): D12.644.276.923.374, D12.776.467.923.374, D23.529.923.374

MeSH Unique ID: D040121

Entry Terms:

  • Sem D
  • Semaphorin D
  • Collapsin-1
  • Collapsin 1
  • Sema3A
  • Semaphorin 3A
  • Collapsing Factor
  • Collapsin

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