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Receptors, Notch

A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.

Year introduced: 2006(1990)

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Subheadings:

Tree Number(s): D12.776.543.750.725, D12.776.930.770

MeSH Unique ID: D051880

Entry Terms:

  • Notch Proteins
  • Notch Receptors

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