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Receptors, LDL

Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.

Year introduced: 1985

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Tree Number(s): D12.776.543.750.710.450

MeSH Unique ID: D011973

Entry Terms:

  • LDL Receptors
  • LDL Receptors, Lipoprotein
  • Receptors, Lipoprotein LDL
  • Lipoprotein LDL Receptors
  • Low Density Lipoprotein Receptors
  • Receptors, Lipoprotein, LDL
  • Receptors, Low Density Lipoprotein
  • LDL Receptor
  • Receptor, LDL
  • Low Density Lipoprotein Receptor

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