Receptors, LDL

Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.

Year introduced: 1985

PubMed search builder options

Subheadings:

Restrict to MeSH Major Topic.

Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): D12.776.543.750.710.450

MeSH Unique ID: D011973

Entry Terms:

• LDL Receptors
• LDL Receptors, Lipoprotein
• Receptors, Lipoprotein LDL
• Lipoprotein LDL Receptors
• LDL Receptor
• Receptor, LDL
• Low Density Lipoprotein Receptors
• Receptors, Lipoprotein, LDL
• Receptors, Low Density Lipoprotein
• Low Density Lipoprotein Receptor

Previous Indexing:

• Lipoproteins, LDL (1972-1984)
• Receptors, Endogenous Substances (1973-1984)

See Also:

• Lipoproteins, LDL

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Membrane Proteins
Receptors, Cell Surface
Receptors, Lipoprotein
Receptors, LDL
LDL-Receptor Related Proteins
Low Density Lipoprotein Receptor-Related Protein-1
Low Density Lipoprotein Receptor-Related Protein-2
Low Density Lipoprotein Receptor-Related Protein-5
Low Density Lipoprotein Receptor-Related Protein-6
Receptors, Oxidized LDL
Scavenger Receptors, Class E +
Receptors, Scavenger
Scavenger Receptors, Class A
Scavenger Receptors, Class B +
Scavenger Receptors, Class C
Scavenger Receptors, Class D +
Scavenger Receptors, Class E +
Scavenger Receptors, Class F