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Receptor, trkA

A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.

Year introduced: 2000

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Subheadings:

Tree Number(s): D08.811.913.696.620.682.725.400.660, D12.776.543.750.630.496, D12.776.543.750.750.400.550.550

MeSH Unique ID: D020917

Registry Number: EC 2.7.10.1

Entry Terms:

  • Proto-Oncogene Protein trk
  • Proto Oncogene Protein trk
  • trk, Proto-Oncogene Protein
  • gp140(c-TRK)
  • trk Proto-Oncogene Protein
  • Proto-Oncogene Protein, trk
  • trk Proto Oncogene Protein
  • NTRK1 Receptor
  • Receptor, NTRK1
  • Proto-Oncogene Products c-trk
  • Proto Oncogene Products c trk
  • c-trk, Proto-Oncogene Products
  • c-trk Protein
  • c trk Protein
  • gp140 c-trk
  • c-trk, gp140
  • gp140 c trk
  • p140-trkA
  • p140 trkA
  • trk1 Transforming Tryrosine Kinase
  • Neurotrophic Tyrosine Kinase Receptor Type 1
  • trkA Receptor
  • Receptor, Neurotrophic Tyrosine Kinase Type 1

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