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Receptor, Insulin

A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.

Year introduced: 2000(1977)

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Subheadings:

Tree Number(s): D08.811.913.696.620.682.725.400.200, D12.776.543.750.630.484, D12.776.543.750.750.580.300

MeSH Unique ID: D011972

Registry Number: EC 2.7.10.1

Entry Terms:

  • Receptors, Insulin
  • Insulin Receptors
  • Insulin Receptor Protein-Tyrosine Kinase
  • Insulin Receptor Protein Tyrosine Kinase
  • Insulin Receptor
  • Insulin-Dependent Tyrosine Protein Kinase
  • Insulin Receptor beta Subunit
  • Insulin Receptor beta Chain
  • Insulin Receptor alpha Subunit
  • Insulin Receptor alpha Chain

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