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RNA, Small Interfering

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

Year introduced: 2003

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Tree Number(s): D13.150.650.700, D13.444.735.150.700, D13.444.735.790.552.875

MeSH Unique ID: D034741

Entry Terms:

  • Interfering RNA, Small
  • Small Interfering RNA
  • Short Interfering RNA
  • Interfering RNA, Short
  • RNA, Short Interfering
  • siRNA
  • Short Hairpin RNA
  • Hairpin RNA, Short
  • RNA, Short Hairpin
  • Small Hairpin RNA
  • Hairpin RNA, Small
  • RNA, Small Hairpin
  • shRNA
  • Scan RNA
  • scnRNA
  • Small Scan RNA
  • RNA, Small Scan
  • Scan RNA, Small
  • RNA, Scan
  • Trans-Acting siRNA
  • Trans Acting siRNA
  • tasiRNA
  • siRNA, Trans-Acting
  • siRNA, Trans Acting
  • Repeat-Associated siRNA
  • Repeat Associated siRNA
  • siRNA, Repeat-Associated
  • siRNA, Repeat Associated

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