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RNA Interference

A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.

Year introduced: 2003

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Tree Number(s): G05.308.203.374.790

MeSH Unique ID: D034622

Entry Terms:

  • Interference, RNA
  • RNAi
  • Posttranscriptional Gene Silencing
  • Gene Silencing, Posttranscriptional
  • Gene Silencings, Posttranscriptional
  • RNA Silencing
  • Post-Transcriptional Gene Silencing
  • Post Transcriptional Gene Silencing
  • Post-Transcriptional Gene Silencings
  • Silencing, Post-Transcriptional Gene
  • Gene Silencing, Post-Transcriptional
  • Gene Silencing, Post Transcriptional
  • Cosuppression
  • Co-Suppression
  • Co Suppression

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