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Quinone Reductases

NAD(P)H:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distinguished by their sensitivity to various inhibitors. EC 1.6.99.2 (NAD(P)H DEHYDROGENASE (QUINONE);) is a flavoprotein which reduces various quinones in the presence of NADH or NADPH and is inhibited by dicoumarol. EC 1.6.99.5 (NADH dehydrogenase (quinone)) requires NADH, is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. EC 1.6.99.6 (NADPH dehydrogenase (quinone)) requires NADPH and is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.

Year introduced: 1986(1975)

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Subheadings:

Tree Number(s): D08.811.682.608.800

MeSH Unique ID: D011808

Registry Number: EC 1.6.99.-

Entry Terms:

  • Reductases, Quinone
  • Menaquinone Reductases
  • Reductases, Menaquinone

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