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Proto-Oncogene Proteins c-kit

A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.

Year introduced: 2000(1996)

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Tree Number(s): D08.811.913.696.620.682.725.400.050, D12.776.543.750.630.124, D12.776.543.750.705.852.150.100, D12.776.543.750.750.400.200.170, D12.776.624.664.700.183

MeSH Unique ID: D019009

Registry Number: EC 2.7.10.1

Entry Terms:

  • Proto Oncogene Proteins c kit
  • c-kit, Proto-Oncogene Proteins
  • Stem Cell Factor Receptor
  • SCF Receptor
  • p145 c-kit
  • c-kit, p145
  • p145 c kit
  • p145(c-kit)
  • p145c-kit
  • p145c kit
  • CD117 Antigen
  • Antigens, CD117
  • CD117 Antigens
  • Proto-Oncogene Protein c-kit
  • Proto Oncogene Protein c kit
  • c-kit, Proto-Oncogene Protein
  • c-kit Protein
  • c kit Protein
  • kit Proto-Oncogene Protein
  • Proto-Oncogene Protein, kit
  • kit Proto Oncogene Protein
  • Receptor, Stem Cell Factor
  • Proto-Oncogene Protein kit
  • Proto Oncogene Protein kit
  • c-kit Receptor
  • c kit Receptor

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