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Properdin

A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.

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Subheadings:

Tree Number(s): D12.776.124.486.274.965, D12.776.124.790.223.624, D12.776.377.715.182.624

MeSH Unique ID: D011414

Registry Number: 11016-39-0

Entry Terms:

  • Complement Factor P
  • Factor P, Complement

Pharmacologic Action:

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