Progeria

An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature graying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.

PubMed search builder options

Subheadings:

Restrict to MeSH Major Topic.

Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): C16.320.488.875, C16.320.565.753, C18.452.648.753

MeSH Unique ID: D011371

Entry Terms:

• Hutchinson-Gilford Syndrome
• Hutchinson Gilford Syndrome
• Hutchinson Gilford Progeria Syndrome
• Hutchinson-Gilford Progeria Syndrome
• Hutchinson-Gilford Progeria Syndromes
• Progeria Syndrome, Hutchinson-Gilford
• Progeria Syndromes, Hutchinson-Gilford

See Also:

• Cockayne Syndrome
• Werner Syndrome

All MeSH Categories
Diseases Category
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Genetic Diseases, Inborn
Laminopathies
Progeria

All MeSH Categories
Diseases Category
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Genetic Diseases, Inborn
Metabolism, Inborn Errors
Progeria

All MeSH Categories
Diseases Category
Nutritional and Metabolic Diseases
Metabolic Diseases
Metabolism, Inborn Errors
Progeria