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Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.

Year introduced: 2007

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Tree Number(s): D12.776.543.696

MeSH Unique ID: D053763

Entry Terms:

  • Presenilin

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