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Presenilin-2

Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.

Year introduced: 2007

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Tree Number(s): D12.776.543.696.750

MeSH Unique ID: D053766

Entry Terms:

  • Presenilin 2

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