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Pancreatic Polypeptide

A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.

Year introduced: 1979

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Tree Number(s): D06.472.699.587.700, D12.644.400.600, D12.644.548.586.700, D12.776.631.650.600

MeSH Unique ID: D010191

Registry Number: 59763-91-6

Entry Terms:

  • Pancreatic Polypeptide (PP)
  • Pancreatic Polypeptide Hormone
  • Pancreatic Prohormone

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