PTEN Phosphohydrolase
A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.
Year introduced: 2006(1997)
PubMed search builder options
Subheadings:
Tree Number(s): D08.811.277.352.650.850, D12.776.476.590, D12.776.624.776.695
MeSH Unique ID: D051059
Registry Number: EC 3.1.3.67
Entry Terms:
- Phosphohydrolase, PTEN
- PTEN Protein Phosphatase
- Phosphatase, PTEN Protein
- Protein Phosphatase, PTEN
- PTEN Protein
- PTEN Phosphatase
- Phosphatase, PTEN
- Mutated In Multiple Advanced Cancers 1 Protein
- MMAC1 Protein
- Phosphatase and Tensin Homologue on Chromosome Ten Protein