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ATP Binding Cassette Transporter, Subfamily B

A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.

Year introduced: 2019 (1999)

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Tree Number(s): D12.776.157.530.100.075, D12.776.157.530.450.074.500.500.250, D12.776.395.550.020.400, D12.776.543.550.192.400, D12.776.543.585.100.200, D12.776.543.585.450.074.500.500.250

MeSH Unique ID: D018435

Entry Terms:

  • ATP-Binding Cassette, Sub-Family B Proteins
  • ATP Binding Cassette, Sub Family B Proteins
  • Multidrug Resistance Proteins
  • ATP Binding Cassette Transporter, Sub-Family B
  • ATP Binding Cassette Transporter, Sub Family B
  • P-Glycoproteins
  • P Glycoproteins

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