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Nitric Oxide

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

Year introduced: 1965

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Tree Number(s): D01.339.387, D01.625.550.500, D01.625.700.500, D01.650.550.587.600

MeSH Unique ID: D009569

Registry Number: 31C4KY9ESH

Entry Terms:

  • Oxide, Nitric
  • Nitrogen Monoxide
  • Monoxide, Nitrogen
  • Nitric Oxide, Endothelium-Derived
  • Endothelium-Derived Nitric Oxide
  • Nitric Oxide, Endothelium Derived
  • Endogenous Nitrate Vasodilator
  • Nitrate Vasodilator, Endogenous
  • Vasodilator, Endogenous Nitrate
  • Mononitrogen Monoxide
  • Monoxide, Mononitrogen

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Pharmacologic Action:

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