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Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)

Year introduced: 1963

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Tree Number(s): C01., C01.150.252.400.794.840.500.750, C01.150.252.400.840.500.750, C01.207.180.600, C10.

MeSH Unique ID: D009494

Entry Terms:

  • Syphilis, Central Nervous System
  • Central Nervous System Syphilis
  • Syphilis, CNS
  • General Paralysis
  • General Paralysis of the Insane
  • Paralysis, General
  • General Paresis
  • Paretic Neurosyphilis
  • General Paresis of the Insane
  • Juvenile Paresis
  • Neurosyphilis, Asymptomatic
  • Neurosyphilis, Gummatous
  • Neurosyphilis, Juvenile
  • Neurosyphilis, Secondary
  • Secondary Neurosyphilis
  • Neurosyphilis, Symptomatic

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