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Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.

Year introduced: 1997

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Tree Number(s): D08.811.277.656.300.480.600, D08.811.277.656.675.374.600, D23.050.285.550, D23.101.140.500

MeSH Unique ID: D015260

Registry Number: EC

Entry Terms:

  • CALLA Antigen
  • Enkephalinase
  • Enkephalinase-24.11
  • Enkephalinase 24.11
  • Kidney-Brush-Border Neutral Proteinase
  • Kidney Brush Border Neutral Proteinase
  • Neutral Proteinase, Kidney-Brush-Border
  • Membrane Metallo-Endopeptidase
  • Membrane Metallo Endopeptidase
  • Metallo-Endopeptidase, Membrane
  • Neutral Endopeptidase
  • Endopeptidase, Neutral
  • Neutral Endopeptidase 24.11
  • Endopeptidase 24.11, Neutral
  • Thermolysin-Like Metalloendopeptidase
  • Metalloendopeptidase, Thermolysin-Like
  • Thermolysin Like Metalloendopeptidase
  • YGG-Forming Enzyme
  • Enzyme, YGG-Forming
  • YGG Forming Enzyme
  • Common Acute Lymphoblastic Leukemia Antigens
  • Antigens, Leukemia, Common Acute Lymphoblastic
  • Atriopeptidase
  • CD10 Antigen
  • Antigen, CD10
  • Antigens, CD10
  • CD10 Antigens
  • Endopeptidase-24.11
  • Endopeptidase 24.11
  • Enkephalin Dipeptidyl Carboxypeptidase
  • Carboxypeptidase, Enkephalin Dipeptidyl
  • Dipeptidyl Carboxypeptidase, Enkephalin

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