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NFATC Transcription Factors

A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.

Year introduced: 2006(1993)

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Subheadings:

Tree Number(s): D12.776.930.608

MeSH Unique ID: D050778

Entry Terms:

  • Transcription Factors, NFATC
  • Transcription Factor NF-AT
  • NF-AT, Transcription Factor
  • Transcription Factor NF AT
  • Nuclear Factor of Activated T-Cells, Cytoplasmic
  • Nuclear Factor of Activated T Cells, Cytoplasmic
  • NFAT Proteins
  • NFATC Proteins
  • Nuclear Factors of Activated T-Cells
  • Nuclear Factors of Activated T Cells
  • NF-AT Proteins
  • NF AT Proteins
  • NFAT Transcription Factor 4
  • NFATC3 Transcription Factor
  • Factor, NFATC3 Transcription
  • Transcription Factor, NFATC3
  • NFATx Protein
  • Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein
  • Nuclear Factor of Activated T Cells, Cytoplasmic 3 Protein
  • NF-AT4 Protein
  • NF AT4 Protein
  • NFAT4 Protein
  • NFATC3 Protein
  • NFAT Transcription Factor 2
  • NFAT-2 Protein
  • NFAT 2 Protein
  • Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein
  • Nuclear Factor of Activated T Cells, Cytoplasmic 1 Protein
  • NFATC1 Protein
  • NFATC1 Transcription Factor
  • Factor, NFATC1 Transcription
  • Transcription Factor, NFATC1
  • NF-ATc1 Protein
  • NF ATc1 Protein
  • NFAT2 Protein
  • NFAT Transcription Factor 3
  • NFATC4 Transcription Factor
  • Transcription Factor, NFATC4
  • NFAT3 Protein
  • NFATC4 Protein
  • Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein
  • Nuclear Factor of Activated T Cells, Cytoplasmic 4 Protein
  • NF-AT3 Protein
  • NF AT3 Protein
  • NFAT Transcription Factor 5
  • Nuclear Factor of Activated T-Cells 5 Protein
  • Nuclear Factor of Activated T Cells 5 Protein
  • OREBP Protein
  • Osmotic Response Element Binding Protein
  • NFATL1 Protein
  • Tonicity-Responsive Enhancer-Binding Protein
  • Tonicity Responsive Enhancer Binding Protein
  • NFAT5 Protein
  • NFATz Protein
  • TonEBP Protein
  • NFAT Transcription Factor 1
  • NFATC2 Transcription Factor
  • Factor, NFATC2 Transcription
  • Transcription Factor, NFATC2
  • NFAT1 Protein
  • NFATC2 Protein
  • Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein
  • Nuclear Factor of Activated T Cells, Cytoplasmic 2 Protein
  • NFAT-1 Protein
  • NFAT 1 Protein

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