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Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.

Year introduced: 2003

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Tree Number(s): D13.150.650.319, D13.444.735.150.319, D13.444.735.790.552.500

MeSH Unique ID: D035683

Entry Terms:

  • MicroRNA
  • miRNAs
  • Micro RNA
  • RNA, Micro
  • miRNA
  • Primary MicroRNA
  • MicroRNA, Primary
  • Primary miRNA
  • miRNA, Primary
  • pri-miRNA
  • pri miRNA
  • RNA, Small Temporal
  • Temporal RNA, Small
  • stRNA
  • Small Temporal RNA
  • pre-miRNA
  • pre miRNA

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