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MELAS Syndrome

A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)

Year introduced: 1993

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Tree Number(s): C05.651.460.620.520, C10.228.140.163.100.535, C10.228.140.300.275.500, C10.668.491.500.500.500, C14.907.253.329.500, C16.320.565.189.535, C18.452.132.100.535, C18.452.648.189.535, C18.452.660.560.620.520

MeSH Unique ID: D017241

Entry Terms:

  • Syndrome, MELAS
  • Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes
  • Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode
  • Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke
  • MELAS
  • Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

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