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Lovastatin

A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.

Year introduced: 1988

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Subheadings:

Tree Number(s): D02.455.426.559.847.638.400, D04.615.638.400

MeSH Unique ID: D008148

Registry Number: 9LHU78OQFD

Entry Terms:

  • Mevinolin
  • Monacolin K
  • 6-Methylcompactin
  • 6 Methylcompactin
  • MK-803
  • MK 803
  • MK803
  • Mevacor
  • Lovastatin, (1 alpha(S*))-Isomer
  • Lovastatin, 1 alpha-Isomer
  • 1 alpha-Isomer Lovastatin
  • Lovastatin, 1 alpha Isomer
  • alpha-Isomer Lovastatin, 1

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