Loss of Heterozygosity

The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.

Year introduced: 1998

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Tree Number(s): G05.365.590.029.530

MeSH Unique ID: D019656

Entry Terms:

• Heterozygosity Loss
• Allelic Loss
• Allelic Losses
• Heterozygosity, Loss of

Previous Indexing:

• Chromosome Deletion (1987-1997)
• Heterozygote (1983-1997)

See Also:

• Hemizygote

All MeSH Categories
Phenomena and Processes Category
Genetic Phenomena
Genetic Variation
Mutation
Allelic Imbalance
Loss of Heterozygosity
Chromosome Deletion
Haploinsufficiency