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Leukemia Inhibitory Factor Receptor alpha Subunit

A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.

Year introduced: 2007

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Subheadings:

Tree Number(s): D12.776.543.750.705.852.583.750, D12.776.543.750.750.400.550.250.750

MeSH Unique ID: D053680

Entry Terms:

  • CD118 Antigens
  • LIF Receptor alpha Subunit
  • Antigens, CD118
  • CD118 Antigen
  • Antigen, CD118

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