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An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion.

Year introduced: 1991(1973)

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Tree Number(s): D08.811.277.656.300.760.471, D08.811.277.656.959.350.471, D12.776.157.427.750.249, D12.776.256.626.816.500.507, D12.776.377.457.507, D12.776.395.507, D12.776.556.579.750.249

MeSH Unique ID: D007781

Registry Number: EC 3.4.21.-

Entry Terms:

  • Lactotransferrin

Pharmacologic Action:

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