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Kininogen, High-Molecular-Weight

A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)

Year introduced: 1998

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Subheadings:

Tree Number(s): D12.644.276.812.654.350, D12.776.124.125.635.480, D12.776.467.812.654.350, D12.776.811.420.350, D23.119.630.480, D23.469.050.375.425.350, D23.529.812.654.350

MeSH Unique ID: D019679

Entry Terms:

  • Kininogen, High Molecular Weight
  • High Molecular Weight Kininogens
  • Kininogens, High Molecular Weight
  • HMWK
  • High-Molecular-Weight Kininogens
  • Kininogens, High-Molecular-Weight
  • High-Molecular-Weight Kininogen
  • Fitzgerald Factor
  • High Molecular Weight Kininogen

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