Keratins
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Year introduced: 2007(1966)
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Subheadings:
Tree Number(s): D05.750.078.593.450, D12.776.220.475.450, D12.776.860.607
MeSH Unique ID: D007633
Registry Number: 68238-35-7
Entry Terms:
- Cytokeratin
- Keratin
- Keratin-Associated Proteins
- Keratin Associated Proteins
- Keratin Associated Protein
- Associated Protein, Keratin
- Protein, Keratin Associated
- alpha-Keratin
- alpha Keratin
See Also: