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Iron Regulatory Protein 1

A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.

Year introduced: 2003

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Subheadings:

Tree Number(s): D08.811.520.241.300.050.500, D12.776.157.427.374.375.960, D12.776.157.725.374, D12.776.494.500, D12.776.556.579.374.375.960, D12.776.664.962.374

MeSH Unique ID: D035941

Registry Number: EC 4.2.1.3

Entry Terms:

  • IRP-1 Protein
  • IRP 1 Protein
  • IRP1 Protein
  • ACO1 Protein
  • Aconitase 1, Soluble
  • Soluble Aconitase 1
  • IRE-BP1
  • IRE BP1
  • Ferritin Repressor Protein
  • Repressor Protein, Ferritin

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