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A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.

Year introduced: 1995 (1991)

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Tree Number(s): D12.644.276.374.465.512, D12.776.467.374.465.512, D23.529.374.465.512

MeSH Unique ID: D018664

Registry Number: 187348-17-0

Entry Terms:

  • Natural Killer Cell Stimulatory Factor
  • IL-12
  • Cytotoxic Lymphocyte Maturation Factor
  • IL 12
  • IL-12 p70
  • Interleukin-12 p70
  • Interleukin 12 p70
  • Interleukin 12
  • IL12
  • Edodekin Alfa

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