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A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.

Year introduced: 1990(1983)

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Tree Number(s): D12.644.276.374.465.010, D12.644.276.374.500.400, D12.776.467.374.465.010, D12.776.467.374.500.400, D23.529.374.465.131, D23.529.374.500.400

MeSH Unique ID: D007375

Entry Terms:

  • Interleukin 1
  • Epidermal Cell Derived Thymocyte-Activating Factor
  • Epidermal Cell Derived Thymocyte Activating Factor
  • IL-1
  • Interleukin I
  • Lymphocyte-Activating Factor
  • Lymphocyte Activating Factor
  • Macrophage Cell Factor
  • T Helper Factor

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