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An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not phosphoramidon. (Eur J Biochem 1994;223:1-5) EC

Year introduced: 1997

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Tree Number(s): D08.811.277.656.300.480.300, D08.811.277.656.675.374.300

MeSH Unique ID: D007339

Registry Number: EC

Entry Terms:

  • Insulin-Degrading Enzyme
  • Enzyme, Insulin-Degrading
  • Insulin Degrading Enzyme
  • Insulin Protease
  • Protease, Insulin
  • Insulin Proteinase
  • Proteinase, Insulin
  • Insulinase

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