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Insulin-Like Growth Factor Binding Protein 1

One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)

Year introduced: 2005(1992)

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Tree Number(s): D12.776.157.420.250

MeSH Unique ID: D018970

Entry Terms:

  • Insulin Like Growth Factor Binding Protein 1
  • IGFBP-1
  • IGF-Binding Protein 1
  • IGF Binding Protein 1

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