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Insulin

A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).

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Subheadings:

Tree Number(s): D06.472.699.587.200.500.625, D12.644.548.586.200.500.625

MeSH Unique ID: D007328

Entry Terms:

  • Insulin, Regular
  • Regular Insulin
  • Soluble Insulin
  • Insulin, Soluble
  • Insulin A Chain
  • Sodium Insulin
  • Insulin, Sodium
  • Novolin
  • Iletin
  • Insulin B Chain
  • Chain, Insulin B

See Also:

Pharmacologic Action:

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