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Inhibitor of Apoptosis Proteins

A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity.

Year introduced: 2006(1997)

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Subheadings:

Tree Number(s): D08.811.464.938.750.210, D12.644.360.075.437, D12.776.476.075.437

MeSH Unique ID: D051034

Entry Terms:

  • Apoptosis Proteins Inhibitor
  • Inhibitor-Of-Apoptosis Protein
  • Inhibitor Of Apoptosis Protein
  • Baculoviral Inhibitor Of Apoptosis Repeat Proteins
  • IAP Repeat Containing Proteins
  • IAP Protein (Apoptosis)
  • Baculoviral IAP Repeat-Containing 2 Protein
  • Baculoviral IAP Repeat Containing 2 Protein
  • Cellular Inhibitor of Apoptosis 1 Protein
  • IAP2 Protein
  • c-IAP1 Protein
  • cIAP1 Protein
  • Inhibitor of Apoptosis 2 Protein
  • BIRC2 Protein
  • Baculoviral IAP Repeat Containing Protein 2

Pharmacologic Action:

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