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Immunoglobulin Joining Region

A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.

Year introduced: 1988

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Tree Number(s): D12.644.541.500.650.500.590, D12.776.124.486.485.680.650.500.590, D12.776.124.486.485.797.590, D12.776.124.790.651.680.650.500.590, D12.776.124.790.651.797.590, D12.776.377.715.548.680.650.500.590, D12.776.377.715.548.797.590

MeSH Unique ID: D007133

Entry Terms:

  • Joining Region, Immunoglobulin
  • Joining Region, Ig
  • Ig Joining Region
  • Immunoglobulin Joining Region Peptide Fragments

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