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Immunoglobulin Fab Fragments

Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

Year introduced: 2006 (1973)

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Subheadings:

Tree Number(s): D12.644.541.500.650, D12.776.124.486.485.680.650, D12.776.124.790.651.680.650, D12.776.377.715.548.680.650

MeSH Unique ID: D007140

Entry Terms:

  • Fab Fragments, Immunoglobulin
  • Immunoglobulins, Fab Fragment
  • Fab Fragment Immunoglobulins
  • Fragment Immunoglobulins, Fab
  • Immunoglobulin Fab Fragment
  • Fab Fragment, Immunoglobulin
  • Fab Immunoglobulin Fragments
  • Immunoglobulin Fragments, Fab
  • Fab Fragments
  • Immunoglobulins, Fab

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