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Immune Tolerance

The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.

Year introduced: 1966(1964)

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Tree Number(s): G12.535.425

MeSH Unique ID: D007108

Entry Terms:

  • Tolerance, Immune
  • Immunosuppression (Physiology)
  • Immunosuppressions (Physiology)

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