Hypoxanthine Phosphoribosyltransferase

An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.

Year introduced: 1975

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Tree Number(s): D08.811.913.400.725.450

MeSH Unique ID: D007041

Registry Number: EC 2.4.2.8

Entry Terms:

• Phosphoribosyltransferase, Hypoxanthine
• Hypoxanthine-Guanine Phosphoribosyltransferase
• Hypoxanthine Guanine Phosphoribosyltransferase
• Phosphoribosyltransferase, Hypoxanthine-Guanine
• IMP Pyrophosphorylase
• Pyrophosphorylase, IMP
• Guanine Phosphoribosyltransferase
• Phosphoribosyltransferase, Guanine
• HPRT
• HPRTase
• HGPRT

Previous Indexing:

• Pentosephosphates (1972-1974)
• Pentosyltransferases (1972-1974)

See Also:

• Gout
• Lesch-Nyhan Syndrome

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Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Transferases
Glycosyltransferases
Pentosyltransferases
Hypoxanthine Phosphoribosyltransferase