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Histocompatibility Antigens Class I

Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.

Year introduced: 1989

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Subheadings:

Tree Number(s): D12.776.395.550.489, D12.776.543.550.439, D23.050.301.500.100, D23.050.705.552.100

MeSH Unique ID: D015395

Entry Terms:

  • Class I Histocompatibility Antigens
  • Class I Antigens
  • Antigens, Class I
  • I Antigens, Class
  • Class I Major Histocompatibility Antigens
  • Human Class I Antigens
  • Class I Human Antigens

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