Histocompatibility Antigens Class I
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Year introduced: 1989
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Subheadings:
Tree Number(s): D12.776.395.550.489, D12.776.543.550.439, D23.050.301.500.100, D23.050.705.552.100
MeSH Unique ID: D015395
Entry Terms:
- Class I Histocompatibility Antigens
- Class I Antigens
- Antigens, Class I
- I Antigens, Class
- Class I Major Histocompatibility Antigens
- Human Class I Antigens
- Class I Human Antigens
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