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Histocompatibility Antigens Class I

Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.

Year introduced: 1989

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Tree Number(s): D12.776.395.550.489, D12.776.543.550.439, D23.050.301.500.100, D23.050.705.552.100

MeSH Unique ID: D015395

Entry Terms:

  • MHC-I Peptide
  • MHC I Peptide
  • Peptide, MHC-I
  • Class I Major Histocompatibility Antigen
  • MHC Class I Molecule
  • MHC Class I Molecules
  • Class I Antigens
  • Antigens, Class I
  • Class I Major Histocompatibility Antigens
  • Class I Histocompatibility Antigens
  • Class I Major Histocompatibility Molecules
  • MHC-I Molecules
  • MHC I Molecules
  • Molecules, MHC-I
  • MHC-I Peptides
  • MHC I Peptides
  • Peptides, MHC-I
  • Class I MHC Proteins
  • Class I MHC Protein
  • Class I Antigen
  • Antigen, Class I
  • I Antigen, Class
  • Class I Histocompatibility Antigen
  • Human Class I Antigens
  • Class I Human Antigens

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