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Helix-Turn-Helix Motifs

The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)

Year introduced: 1996

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Tree Number(s): G02.111.570.820.709.275.500.360.360

MeSH Unique ID: D019077

Entry Terms:

  • Helix Turn Helix Motifs
  • Helix-Turn-Helix Motif
  • Motif, Helix-Turn-Helix
  • Motifs, Helix-Turn-Helix
  • Motifs, Helix Turn Helix
  • HTH Motifs
  • HTH Motif
  • Motif, HTH
  • Motifs, HTH

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