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Granzymes

A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.

Year introduced: 2007(1986)

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Subheadings:

Tree Number(s): D08.811.277.656.300.760.397, D08.811.277.656.959.350.397

MeSH Unique ID: D053804

Registry Number: EC 3.4.21.-

Entry Terms:

  • Granzyme
  • Granzyme M
  • Granzyme C
  • Granzyme K
  • Natural Killer Cell Granule Tryptase-2
  • Natural Killer Cell Granule Tryptase 2
  • NK-Tryptase-2
  • NK Tryptase 2
  • Granzyme-3
  • Granzyme 3
  • Granzyme A
  • Cytotoxic T-Lymphocyte Proteinase 1
  • Cytotoxic T Lymphocyte Proteinase 1
  • Hanukah Factor
  • Granzyme B
  • Fragmentin 2
  • Cytotoxic T-Lymphocyte Associated 1 Protein
  • Cytotoxic T Lymphocyte Associated 1 Protein
  • Granzyme-Like Protein III
  • Granzyme Like Protein III
  • Cytotoxic Serine Protease B

Pharmacologic Action:

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