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Glutamate Decarboxylase

A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC

Year introduced: 1984(1975)

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Tree Number(s): D08.811.520.224.125.250

MeSH Unique ID: D005968

Registry Number: EC

Entry Terms:

  • Decarboxylase, Glutamate
  • Glutamic Acid Decarboxylase
  • Acid Decarboxylase, Glutamic
  • Decarboxylase, Glutamic Acid
  • Glutamate Carboxy-Lyase
  • Carboxy-Lyase, Glutamate
  • Glutamate Carboxy Lyase

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