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Genes, BRCA1

A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways.

Year introduced: 1997

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Subheadings:

Tree Number(s): G05.360.340.024.340.375.249.100, G05.360.340.024.340.415.400.100

MeSH Unique ID: D019398

Entry Terms:

  • BRCA1 Genes
  • Gene, BRCA1
  • BRCA1 Gene

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