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Fusion Proteins, bcr-abl

Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.

Year introduced: 1991

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Tree Number(s): D08.811.913.696.620.682.725.500.500, D12.776.602.500.500.100, D12.776.624.664.500.100, D12.776.624.664.700.171.500

MeSH Unique ID: D016044

Registry Number: EC

Entry Terms:

  • Fusion Proteins, bcr abl
  • bcr-abl Fusion Proteins
  • bcr abl Fusion Proteins
  • Bcr-Abl Tyrosine Kinase
  • Bcr Abl Tyrosine Kinase
  • Kinase, Bcr-Abl Tyrosine
  • Tyrosine Kinase, Bcr-Abl
  • Oncogene Protein p190(bcr-abl)
  • p190(bcr-abl) Fusion Proteins
  • Oncogene Protein p230(bcr-abl)
  • p230(bcr-abl) Fusion Proteins
  • Oncogene Protein p185(bcr-abl)
  • p185(bcr-abl) Fusion Proteins
  • Oncogene Protein p210(bcr-abl)
  • p210(bcr-abl) Fusion Proteins

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