Focal Adhesion Kinase 1
A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.
Year introduced: 2006(1986)
PubMed search builder options
Subheadings:
Tree Number(s): D08.811.913.696.620.682.725.049.500, D12.776.476.568.049.500, D12.776.744.493
MeSH Unique ID: D051417
Registry Number: EC 2.7.10.2
Entry Terms:
- Endogenous Substrate pp120
- p125FAK Protein
- Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK
- Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK
- Protein Tyrosine Kinase 2