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A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Year introduced: 2002 (1990)

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Tree Number(s): G02.111.240, G05.308.200, G07.690.773.937

MeSH Unique ID: D015536

Entry Terms:

  • Down Regulation
  • Downregulation
  • Down-Regulation (Physiology)
  • Receptor Down-Regulation
  • Down-Regulation, Receptor

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