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Dosage Compensation, Genetic

Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.

Year introduced: 2006 (1982)

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Subheadings:

Tree Number(s): G05.308.203.249

MeSH Unique ID: D004303

Entry Terms:

  • Compensation, Genetic Dosage
  • Genetic Dosage Compensation
  • Genetic Dosage Compensations
  • Gene Dosage Compensation
  • Compensation, Gene Dosage
  • Dosage Compensation, Gene
  • Gene Dosage Compensations
  • Dosage Compensation (Genetics)
  • Compensation, Dosage (Genetics)
  • X-Chromosome Hypertranscription
  • X Chromosome Hypertranscription
  • Hypertranscription, X-Chromosome
  • Hypertranscription, X Chromosome

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