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Deoxyribonuclease I

An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.

Year introduced: 1985

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Subheadings:

Tree Number(s): D08.811.277.352.335.350.250

MeSH Unique ID: D003850

Registry Number: EC 3.1.21.1

Entry Terms:

  • DNAase I
  • Pancreatic DNase
  • DNase, Pancreatic
  • Thymonuclease
  • DNA Endonuclease
  • Endonuclease, DNA
  • DNase I
  • Nickase
  • DNA Nicking Enzyme
  • Endonuclease I
  • T4-Endonuclease II
  • T4 Endonuclease II
  • T7-Endonuclease I
  • T7 Endonuclease I
  • Dornavac
  • Streptodornase

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